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Materials (Basel) 2019;12(18):2968

In this review, we highlight insights from recent unbiased phosphoproteomics studies, which have enabled a comprehensive examination of insulin signalling and have transformed our perspective on how signalling changes may contribute to insulin resistance

Moreover, butyrate results in elevated oxidative stress and subsequent lipid peroxidation owing to the disruption of mitochondrial energy metabolism

Research on LL29 (IPF lung fibroblasts), NHLF (normal lung fibroblasts), and DHLF (diseased lung fibroblasts) cells showed that biochanin-A increased Smad7 expression and decreased Smad2 mRNA expression, indicating inactivation of the TGF-/Smad signaling pathway [129]

10.1093/ibd/izad099 [DOI] [PMC free article] [PubMed] [Google Scholar] Deng M., Zhang Q., Yan L., Bian Y., Li R., Gao J., et al
