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SELENOS has a role in the removal of stressor-induced misfolded proteins from the ER, preventing the accumulation of these proteins and the subsequent stress response that leads to activation of NF-B, pro-inflammatory cytokine gene transcription and the inflammation cascade (Fig

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However, Hcy shows a significant inverse correlation with serum folate ( r = 0.310

Glutathione plays a role in protecting neurons from oxidative damage, supporting cognitive clarity, and maintaining vascular function through improved endothelial health

They can also respond to intracellular events such as ROS or intracellular receptors (Torres, 2003)