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Proc Natl Acad Sci U S A 116 , 29963005 (2019)

The Coombs test, also called the direct antiglobulin test (or DAT), can be used when IMHA is suspected but macroagglutination or microagglutination is not evident

Conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Hashimotos thyroiditis, and coeliac disease are commonly associated with symptoms including joint pain, digestive disturbances, and fatigue commonly seen in autoimmune conditions (46)

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Trade-offs are most clearly detected at the level of metabolic constraints or short-term resource limitation, whereas field-based metabolomic patterns integrate responses across tissues, developmental stages, and fluctuating environments (Zidorn, 2010