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The present systematic review and meta-analysis included four strengths: (1) the study included a comprehensive analysis of 107 full-text articles, providing a broad overview of the existing literature on the association between GSTT1 polymorphism and the risk of HNC

2023;15:e50979

doi: 10.1146/annurev.ps.17.020166.002051, 61 Herrero-MendezA.AlmeidaA.FernndezE.MaestreC.MoncadaS.BolaosJ

Inhibition of NRF2 activity and decreased GSH levels are direct consequences of the T790M mutation Although lower GSH levels and NRF2 activity were associated with T790M-driven erlotinib resistance in our cell lines, this may still be incidental unless the T790M mutation directly induces these changes