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Its active ingredients, witanolides and alkaloids, are essential to pharmacological action [18]

Ethanol-inducible CYP2E1 has an important role in EtOH metabolism, particularly in chronic alcohol users 33

Furthermore, a recent study investigating patients with psoriatic arthritis (PsA) demonstrated that various biologic agents including infliximab, adalimumab, etanercept, golimumab, certolizumab, ustekinumab, and secukinumab were associated with an overall protective effect against liver fibrosis in individuals with MASLD

Fatty acyl-CoA reductase 1 (FAR1) is an essential factor for SFAs-mediated ferroptosis by converting SFAs to fatty alcohol, which is required for the synthesis of alkyl-ether lipids and plasmalogens (Fig