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Clomiphene and cyclofenil are also older SERMs (although perhaps less selective than tamoxifen) (Heuberger and Cohen, 2019)

The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

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doi:10.1016/j.molmet.2020.101102 Graaf C, Donnelly D, Wootten D, et al
