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The number of intravitreal injections performed annually in the United States rose from less than 3000 in 1999 to more than 1 million in 2008, 1 and it is estimated that more than 7 million intravitreal injections will be performed in the United States in 2017
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Peroxynitrite can initiate DNA damage, leading to the stimulation of a nuclear enzyme, poly (ADP-ribose) synthase (PARS), which causes a decrease in cellular energy levels and leads to cell death

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Its 12-month safety profile in long-term studies adds confidence for the extended treatment periods that TBI recovery demands
