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IHC positivity was reported for S100 (69%), HMB45 (63%), MelanA (31%), and MiTF (3%)
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In the phase II trial (ClinicalTrials.gov identifier: NCT03013543), setmelanotide resulted in the reduction of body weight and hyperphagia (assessed by hunger scores) after 3 months in patients with heterozygous POMC mutations, including PCSK1, LEPR, SRC1 and SH2B1 variants
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