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Description
Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli

However, the large size of the therapeutic molecule restricts its access to tumour cells, particularly in central regions of solid tumours (Russell et al, 1992)

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2014 Jun 17;48(12):7062-8