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This increase in bone density was attributed to a decrease in osteoclast, as well as, inflammatory cytokines in the bone and bone marrow in the germ free mice vs conventionally raised mice [132]

doi: 10.1111/j.1600-0463.2010.02631.x 22 LvSTeugelsESadonesJDe BrakeleerSDuerinckJDu FourSet al

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When mitochondrial capacity is compromised, these trade-offs become more pronounced, leaving insufficient energy to sustain robust immune responses ( Additionally, heat stress suppresses the expression of transporters such as SLC38A10 (amino acid transport) and SLC2A1 / GLUT1 (glucose transport), while repressing PPAR-mediated metabolic pathways in dairy cows, further limiting cellular fuel availability, weakening mitochondrial integrity, and imposing energetic constraints on immunity (Wheelock et al., 2010

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