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Store-operated Ca 2+ channels and stromal interaction molecule 1 (STIM1) are targets for the actions of bile acids on liver cells

The presence of a cord is a cause of discomfort and pain associated with IV therapy, and makes it more difficult for an IV line to be placed as a line cannot be placed in an area with a cord

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A major challenge is the wide heterogeneity in initial presentation and rates of progression, which is partly underpinned by variation in underlying pathological accumulations 2