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It does not appear that DORs inhibit glutamate input from thalamus ( The early study of opioid effects on neurotransmission in dorsal striatum concluded that KORs have no effect on glutamate release (Jiang and North, 1992)
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Interestingly, Day 45 organoids exhibited a shift toward a mesenchymal cell profile, with increased markers of hepatic stellate cells, suggesting utility for disease modeling applications
