increase your bodies production of acetyl-l-carnitine Carnitine in Human Muscle Bioenergetics: Can Carnitine Supplementation Improve Physical Exercise? PCOS Nutrition Center L-Carnitine Subscription

During intense exercise, lactic acid builds up in the muscles, leading to a decrease in pH and an increase in muscle fatigue

CPT1 conjugates carnitine with long chain fatty acids, carnitine acylcarnitine translocase (CACT) transfers the acylcarnitine across the inner plasma membrane and CPT2 conjugates the fatty acid back to Coenzyme A for subsequent -oxidation

Because KAT6A contains multiple functional domains, it is possible that ARTHS variants may result in a truncated protein that retains acetyltransferase activity but lacks proteinprotein interaction domains that regulate this activity

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Formenti A, Arrigoni E, Sansone V, et al