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340 Therapeutic leverage of ROS elevation in cancer treatment Since the 1950s, various strategies/drug research have been implemented based on this concept, such as administering ROS or ROS-generating enzymes to tumor cell lines or murine models with tumors

Moreover, amino acid metabolism regulates the redox balance through the generation of nicotinamide adenine dinucleotide phosphate (NADPH) and reduced glutathione (GSH), which are essential for cellular defense against oxidative stressa key driver in IPF progression [7, 19]

Parian, A

Touchscreen testing reveals clinically relevant cognitive abnormalities in a mouse model of schizophrenia lacking metabotropic glutamate receptor 5