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To further examine the possibility that MK-801 could convey protraction, we synthesized a series of conjugates comprising MK-801 in combination with other peptide analogues, peptide YY (PYY), glucose insulinotropic peptide (GIP) as well as a GIP/GLP-1 co-agonist, for which half-life extension has been shown to enhance weight loss efficacy 23,24,25,26

10.1080/07420528.2024.2414045 93 KochB

Taken together, these results suggested that lactate is preferentially taken up by detached ER + breast cancer cells (may be dependent on ALDH status) and incorporated into the TCA cycle as a fuel

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