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The world-wide prevalence of the disease has been reported to be approximately 1%, with a male-to-female ratio of 4:1 4

Treatment with the soluble TNF- receptor etanercept or the JAK inhibitor tofacitinib reversed CRPS IgGinduced hyperalgesia and microglial activation were reversed (134)

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2019;95, article 109673 doi: 10.1016/j.pnpbp.2019.109673

The tools with the strongest evidence for anxiety and mood support include consistent sleep (seven-plus hours, regular schedule), regular physical activity (both resistance training and cardiovascular exercise have demonstrated antidepressant and anxiolytic effects), therapy or coaching for cognitive and behavioral patterns, mindfulness or stress-management practices, and social connection