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8.10 Biochemical effects Biochemical effects have been observed in cultured hepatocytes, liver homogenates and mitochondrial fractions, purified enzymes, isolated hepatic lipid membranes and whole liver preparations, including: metabolic effects on lipid peroxidation (Stege, 1982

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responsible for tau hyperphosphorylation) ( via down-regulation of GSK -3 transcription as well as via activation of transient receptor potential vallinoid 1 (TRPVI) and subsequent promotion of phosphatidylinositol 3-kinase/Akt kinase (PI3K/Akt) signaling in mesenchymal stem cells (Libro et al., 2016)

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