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Systemic administration of gabapentin induced significant dose-dependent decreases in the elevated spontaneous and thermally-evoked ventrolateral periaqueductal gray neuronal firing to both non-noxious and noxious thermal stimuli in paclitaxel-treated rats but not in nave rats

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For instance, individuals found to have a GST mutation might be advised to avoid certain environmental carcinogens, such as cigarette smoke, or might be more closely monitored for the early detection of certain types of cancer