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Linda Im in the USA and doctors here are reluctant to prescribe these shots unless there is a severe deficiency

Clinical evidence comes in tiers: mechanistic studies (does the molecule do what it should at the cellular level?), animal studies (does it produce the expected effect in a living organism?), and human trials (does it actually work on the people who will use it?)

[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Fedulova L., Vasilevskaya E., Tikhonova O., Kazieva L., Tolmacheva G., Makarenko A

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That alone may be enough to act on if your goals are cosmetic rather than medical