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Besides in vitro cell culture models, organoids and simpler organisms, such as invertebrates, have been suggested to avoid classical animal testing with rodents or other mammals
Plant Physiology 129, 16421650
Burrows, R
The IGF1-binding site is formed by the L1 and CR domains (CRD) of one IGF1R protomer, and the -CT and FnIII-1 domains of the other
