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Inoculation did not significantly affect the reduced glutathione concentration of two resistant genotypes (Figure 2 F)
These findings underscore FSP1s independent role in tumor maintenance and its potential as a stand-alone therapeutic target

Sharon G, Sampson TR, Geschwind DH, Mazmanian SK

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

Using isogenic panels of colorectal cell lines harbouring the G12A, G12C, G12D and G12V heterozygous mutations and employing transcriptomics, metabolomics, and extensive biochemical validation, we characterise distinctive features of each allele
