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Wang E, Sun H, Wang J et al (2019) End-point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design

[168], he proposed that NO may bind to the enzymes of mitochondrial ETC, such as NADH succinate oxidoreductase, NADH ubiquinone oxidoreductase, and cis aconitase and induce uncoupling of OXPHOS followed by the inhibition of glycolysis [66] and depletion of ATP in the cells [169]

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