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Some trials observed effects on IGF-I and protein metabolism, suggesting MK-677 may play a role in managing muscle-wasting conditions, although the exact mechanism and long-term benefits are still under investigation
Detrusor smooth muscle hypertrophy compensates for the increased muscle contractility required to overcome increased urethral resistance during urination ( Functional assessments of rats with pBOO revealed significant increases in MVP, MBC, RV, and voiding frequency in rats with pBOO, accompanied by decreases in BC and VE
Radiology 184: 123-130
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