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[11] Most published studies were designed for efficacy assessment, not comprehensive toxicological screening

When the proteins with low participation percentages in linear paths are evaluated according to the criteria of low betweenness and high closeness centrality values, four proteins (LRSAM1, MLTK, MARK1 and miyosin 9) seem to be important for consideration as putative drug targets (either by activation or inhibition) and need further examination (Table 9)

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Importantly, these findings establish SOCS3 and CDKN1A as conserved elements of the DAO state across species, warranting further mechanistic investigation into their roles in OL pathology