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Concurrently, therapy-induced NF-B activation upregulates APOBEC cytidine deaminases, which catalyze cytidine-to-uracil mutations in single-stranded DNA to fuel genomic instability [47, 48]
Protein oxidation can lead to misfolding and aggregation, impairing the cells function
It should be noted that there is concern about endocrine disrupting di (2-ethylhexyl) phthalate (DEHP) leaching from vinyl intravenous bags and tubing [121]
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Moreover, the activation of STAT1 is related to cell apoptosis
