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3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimers disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular -amyloid (A) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability (Hooper et al., 2025)

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In line with this trend, the total concentration of non-conjugated secondary BAs was significantly ( P = 0.008) higher in FM subjects than in HC (Table 3

doi: 10.1089/ars.2020.8230 185 SunHSherrierMLiH