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Exercise stimulates mitochondrial biogenesis through PGC-1, nuclear respiratory factors (Nrf1 and Nrf2), and mitochondrial transcription factor A (TFAM), leading to enhanced energy metabolism and improved neuronal survival [253, 254]

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The atomic coordinates and structure factors for the reported crystal structures were deposited under accession codes 7E1Q, 7E1R, and 7E1S

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Li, L.-Y

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