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By optimizing PSB composition and delivery, this strategy may overcome the limited efficacy and systemic side effects of current anti-fibrotic drugs, presenting a potential clinical solution for IPF and informing new directions for inhaled therapies of other pulmonary diseases

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In vitro and ex vivo studies showed increased uptake and transport of insulin across buccal mucosa models, while in vivo experiments in rabbits demonstrated a relative pharmacological bioavailability of 26.9% following buccal administration of the conjugate, markedly higher than unconjugated insulin [100]

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