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When Lipid Metabolism Becomes Pathology Familial Hypercholesterolemia LDL receptor defects markedly elevated LDL premature atherosclerosis

While we see a trend for cells with KRAS mutations to be less sensitive to serine and glycine starvation alone, exceptions are likely to reflect other changes that influence the serine synthesis pathway such as PHGDH amplification

Kromer A, Moosmann B

(And, yes, the benefit appeared to evaporate once the supplement was stopped.) Lower doses might fare as well, I suppose, but another trial run by different investigators many of them on Nestls payroll found only marginal benefit in biomarkers with higher dose ranges, and none in the 1200mg cysteine/1200mg NAC dosing found in the Celltrient product

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