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Accessed 6/1/2015
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TMAO in cardiomyocytes triggers TGF1/Smad3/p65 NFB signaling pathways and lowers energy metabolism and mitochondrial function by disrupting pyruvate and fatty oxidation, as well as the TCA cycle
Similarly, lower indole-3-lactic acid levels were reported in 50 ME/CFS patients versus 50 healthy controls
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