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In situ assay of fatty acid beta-oxidation by metabolite profiling following permeabilization of cell membranes

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Recent preclinical studies (Matalka et al., 2024) showed that GHK-Cu reduces the accumulation of beta-amyloid protein and phosphorylated tau protein in cellular models of Alzheimer's disease

We measured MMA concentration by LC-MS/MS in whole brain extracts (Group 2 in Fig S1C, Table S1)

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