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Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Downs syndrome and Alzheimers disease brain

Where glutaminolysis mainly serves the production of energy in the form of ATP, reversed flux through the TCA cycle favors the synthesis of acetyl-CoA (Filipp et al

22, e52972

Still, the function of the CGFS-type Grxs could not be rescued by FeS-coordinating CxxC/S-type Grxs in a yeast grx5 mutant, indicating different roles of the coordinated clusters for the functions of both classes of Grxs 15

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