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Pyruvate-depletion induced dispersion is independent of previously described factors contributing to dispersion Considering that PDH-exposure of biofilms coincided with dispersion events, we next asked whether pyruvate-depletion induced dispersion requires factors previously demonstrated to be important in dispersion in response to nitric oxide or nutrients 30,46

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Coffey A, Bista S, Mitchell M, Giglia R, Carson R, Lowery M, et al

However, the specific timing should be determined by the hemodynamic status of individual patients and the experience and medical resources of the institution

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