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In response to alterations in body adiposity, the brain triggers compensatory physiological adaptations that resist weight change
It inhibits NNMT, lowering 1-MNA formation while increasing availability of nicotinamide for NAD salvage and SAM for other methylation reactions
Researchers investigate how selective NNMT inhibition affects cellular processes under controlled laboratory conditions
[DOI] [PubMed] [Google Scholar] 134.Wynne K, Park AJ, Small CJ, et al
