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We therefore hypothesised that SFN should have anti-parasitic activity, and determined an IC 50 of 11.8 0.4 M for SFN in a standard growth inhibition assay in Pf3D7 wildtype parasites (Supp Fig 4A)

More studies are needed to elucidate the potential roles of different nuclear receptors and ligands in POMC regulation

Some of these interactions involve the upregulation of CD38, mediated by adipocyte-secreted angiotensin II (Ang II), which has been identified as the direct cause of increased expression of acetyl-CoA synthetase (ACSS2) in MM plasma cells, promoting growth by stabilizing the oncoprotein IRF4 in vitro and in vivo (95)

Biol Psychiatry 46:16491655