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Under rapid stimulation, mitochondrial metabolism may not be the primary mechanism for neuronal ATP production, due to the number of enzymatic steps required for oxidative phosphorylation (Daz-Garca et al

Indeed, GS-ylation impacts on protein function at many levels, from enzymatic activity to protection from oxidative modifications, manipulation of proteins interaction properties and protein stability

In other molecular and neurochemical assays combined with behavioral evaluations, it was found that NAC effectively reversed a drop in the accumbal x c system and GLT-1, seen 7 or 50 days after cue-induced reinstatement, respectively [39, 40]

doi: 10.1126/science.1222278

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