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People with a thalassemia trait have no symptoms or very mild anemia symptoms

Mood swings may signal low vitamin B12 levels, and in more advanced cases, neurological issues such as tingling, nerve pain, or numbness in the hands and feet can arise from untreated B12 deficiency

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Bone marrow as a source of hematopoietic stem cells for human gene therapy of beta-thalassemia

analyzed 272 samples and found a significantly higher -AASA/creatinine ratio in this group of patients with a significant age dependency [24]