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Thus, GSH depletion could be an important factor in the neurological toxicity of EtOH displayed by the elderly

It reduces local inflammation, allowing compressed nerves to begin recovering, and promotes new blood vessel formation to improve the circulation and nutrition that discs desperately need for healing

Since oxidation and inflammation are interconnected processes with many feedback loops 50 , excessive production of ROS and RNS by leukocytes can also trigger inflammatory responses in these immune cells

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Finally, WD repeat domain 23 (WDR23) can form a complex with Damage-Specific DNA Binding Protein 1 (DDB1) and Cullin 4, recognizing and promoting the ubiquitination of NRF2, thereby regulating its stability [21] (Fig