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[DOI] [PubMed] [Google Scholar] 62.Glabowski W, Kurzawa R, Wiszniewska B, Baczkowski T, Marchlewicz M, Brelik P

Carnitine O -acetyltransferase Carnitine O -acetyltransferase (CrAT), located primarily in the mitochondrial matrix, catalyzes the addition or the removal of carnitine from medium- and short-chain acyl-CoA 60,61 , facilitating the efflux of mitochondrial acetyl-CoA to the cytosol and buffering the intracellular pools of acetyl-CoA and carnitine

In addition, the inhibitory effect of malondialdehyde on in vitro CAT activity was inhibited by acetylcarnitine, suggesting a competitive mechanism for the protective effect of acetylcarnitine

1 Environmental or metabolic stressors, including nutritional state, physical activity, hormonal regulation, and pathological conditions such as heart failure, cancer cachexia, and chronic liver disease, require appropriate fuel selection to maintain metabolic homeostasis

There is evidence of potential benefits for endurance and recovery, but the effects vary from person to person and are not guaranteed