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Lipid peroxide accumulation is inhibited by glutathione peroxidase 4 (GPX4), a lipid hydroperoxidase that uses reduced GSH as a cofactor (Friedmann Angeli et al, 2014

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to 80% silymarin

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Lim JH, Luo C, Vazquez F, Puigserver P

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Furthermore, ROS-dependent endoplasmic reticulum stress in tumor cells suppresses DC surface calretinins exposure via autophagy, diminishing their maturation capacity and IL-6 secretion, thereby inhibiting CD4 + /CD8 + T cell proliferation (106)

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