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doi: 10.3389/fphar.2024.1412245 Received 04 April 2024 Accepted 24 June 2024 Published 18 July 2024 Volume 15 - 2024 Edited by Irina Ielciu, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Reviewed by Javad Mottaghipisheh, Swedish University of Agricultural Sciences, Sweden Shaymaa Mahmoud, University of Menoufia, Egypt Ufuk Koca alilkan, Gazi University, Trkiye Aida Abd El-Wahed, Agricultural Research Center, Egypt Gandhi Radis Baptista, Federal University of Ceara, Brazil Updates Copyright 2024 Sadek, Shib, Taher, Rashed, Shukry, Atia, Taymour, El-Nablaway, Ibrahim, Ramadan, Abdelkader, Abdo, Imbrea, Pet, Ali and Abdeen

The common alterations in key metabolic pathways in both FM and ME/CFS suggest a reduced capacity to manage oxidative stress which may underlie the energy metabolism dysfunction and similar symptoms experienced by patients with these conditions

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First-in-human clinical trials present significant challenges, especially concerning participants safety

To test this, we assessed the correlation between oligodendrocyte number and gain rate (Fig