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Essentially, the same mechanisms that make L-arginine beneficial for improving blood flow in muscles also trigger undesirable effects in the gut

The onset of symptoms coincides with a precipitating factor such as excess protein intake, infection, trauma, surgery, deliverance [6] or medications as valproate or glucocorticoids [7]

Those with high visceral fat or insulin resistance

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) Turck D., Bresson J.-L., Burlingame B., Dean T., Fairweather-Tait S., Heinonen M., Hirsch-Ernst K.I., Mangelsdorf I., McArdle H.J., et al