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Description
AstraZeneca executed a version of this strategy with Nexium (esomeprazole) after Prilosec (omeprazole) lost exclusivity, creating a successor product that generated significant revenue even as the predecessor faced generic competition [5]
Theranostics 9 , 75067524 (2019)
Additionally, the treatment altered the levels of certain important molecules within the cells, suggesting changes that could inhibit cancer progression

In human acute liver failure tissue, SIRT1 levels are diminished, however, its activation can mitigate cell damage by modulating the ferroptosis and pyroptosis processes in hepatocytes through the regulation of the p53/GPX4/GSDMD and Nrf2/p53 signaling pathway, thereby exerting a protective effect on the liver (Zhou et al., 2024a)

A new surgical approach for interproximal regenerative procedures
