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Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy

Furthermore, these systems synergistically degrade uric acid via platinum-catalyzed reactions, scavenge ROS using polydopamine, and enhance mitochondrial repair/anti-inflammatory effects through near-infrared-II photothermal therapy-mediated suppression of NF-B signaling and pro-inflammatory cytokine release (Zhao et al., 2024)

Vollset SE, Refsum H, Tverdal A, et al

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found that ROS depletion not only reduced ox-mtDNA production and the binding to NLRP3, but also prevented NLRP3 deubiquitinating, thereby suppressing NLRP3 inflammasome activation