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Dynamic mathematical models, including PBPK models, which consider both human physiology and drug-related parameters, have been extensively used to support the drug discovery and development process

For systemic peptides like MOTS-c or SS-31 , the injection site matters less because the peptide enters systemic circulation regardless of where it is administered

Peptides that are rapidly degraded by salivary enzymes are also poor sublingual candidates

Preclinical characterization of ISB 1342, a CD38xCD3 Tcell engager for relapsed/refractory multiple myeloma

Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper