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(2) Hcy may negatively affect glutathione peroxidase activity and thus transcription of glutathione

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Moreover, LF regulates body fat metabolism limiting obesity (probable downregulation of adipogenic genes and upregulation of fatty acid synthase and acetyl CoA carboxylase in adipocytes) [123,124] and glucose metabolism in patients with type 2 diabetes mellitus via improvement of the insulin-signaling response in adipocytes (up-phosphorylation of Akt serine 473 and up-expression of glucose transport 4 and insulin receptor 1) [107,124,125,126]

doi: 10.1556/2060.106.2019.02

[DOI] [PubMed] [Google Scholar] 127.Ikeda Y., Tajima S., Izawa-Ishizawa Y., Kihira Y., Ishizawa K., Yoshida S., Ken-ichi A., Koichiro T., Toshiaki T