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Our data indicating that PrP plays a role in mediating copper toxicity in WD warrant future studies to evaluate the therapeutic potential of PrP suppression in this and other disorders of copper metabolism

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Headache and fatigue can occur, especially during dose increases

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Murphy RA, Stafford RM, Petrasovits BA, Boone MA, Valentovic MA (2017) Establishment of HK-2 cells as a relevant model to study tenofovir-induced cytotoxicity

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In contrast to GH -/- mice, IGF-1 -/- mice show a proportional reduction in kidney weight when compared to wild-type mice

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