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Another NRF2 activator, UD-051, represents the most recent advancement in this area, developed in 2025 by UBE Corporation in collaboration with Kumamoto University [216]

INCREASED PREVALENCE OF VITAMIN B12 DEFICIENCY IN PATIENTS WITH T2D ON METFORMIN THERAPY: CLINICAL EVIDENCE Determining the prevalence of vitamin B12 deficiency in patients with T2D on metformin therapy is difficult because of the different cutoff values used to define vitamin B12 deficiency, the use or lack of biomarkers in diagnostic criteria, and the heterogeneity of studied populations concerning age, geographical origin, dietary patterns, and duration of metformin use

In HFD-induced obese mouse models, Panax notoginseng saponins were shown to ameliorate hepatic steatosis and fibrosis

5 Conclusions and Prospects This review summarizes the applications of various nanomaterials, including NPs, nanozymes, liposomes, nanofibers, exosomes, and micelles, in treating inflammation-related diseases (Table 1), such as infections, wound healing, liver and kidney injuries, cardiovascular and cerebrovascular diseases, neurological disorders, intestinal inflammation, and rheumatic disorders

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