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2b the data was inadvertently shifted upwards and has now been corrected in the HTML and PDF versions of the article

Nature 439, 682687 (2006)

Bar-Or D, Kulig K, Marx JA et al
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One of the important outcomes of many FIH studies is to determine the MTD of a new therapeutic entity based on the occurrence of particular AEs above a particular severity grade, referred to as DLT