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These data indicate that GSH plays a role in sustaining the activities of CI and CII, and so of the overall ETC
Enzymatic Degradation Although drugs administered to the nasal cavity can avoid gastrointestinal degradation and the hepatic first-pass effect, the nasal cavity contains hydrolytic enzymes as part of its defense mechanism against xenobiotics, leading to enzymatic drug degradation
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[PubMed: 15670198] 278
That concern is justified
